They are used only to adapt the remaining sub-tests to the response characteristics of the individual subject. These results do not count towards the final score. The first sub-battery (visuomotor and visual salience) measures adaptive motor control and dynamic visual contrast sensitivity. This was complimented by clinical research demonstrating letter, word, and motion perceptual deficits in patients with Alzheimer’s disease.Ĭognivue ® consists of 3 sub-batteries of 10 separately scored sub-tests presented in a 10 min automated sequence. It was developed based on extensive basic research into the neural mechanisms of functional impairment in memory, aging, and dementia. Cognivue ® is a physiological and psychophysical computerized tool for the automated assessment of cognitive functioning that is not dependent on traditional question-and-answer testing. In addition, some tests cannot be administered by non-clinicians, and excessive test length can make some tools impractical for routine use in clinical practice. Tools for assessing cognitive function decline are often limited by issues of measurement efficacy, testing bias, inconsistent retest reliability, or cost. Scores were most closely correlated with measures of verbal processing, manual dexterity/speed, visual contrast sensitivity, visuospatial/executive function, and speed/sequencing. Psychometric validity of Cognivue ® was demonstrated vs. Reliability analyses showed similar scores across repeated testing for Cognivue ® ( R 2 = 0.81 r = 0.90) and SLUMS ( R 2 = 0.67 r = 0.82). Cognivue ® classification scores were validated, demonstrating good agreement with SLUMS scores (weighted κ 0.57 95%CI: 0.50-0.63).
For the clinical validation study, 401 participants completed ≥ 1 testing session, and 358 completed 2 sessions 1-2 wk apart. Therefore, conservatively, Cognivue ® scores of 55-64 corresponded to impairment, and 74-79 to no impairment. Analyses showed that SLUMS cut-off scores of 26 (no impairment) corresponded to Cognivue ® scores of 54.5 (NPA = 0.92 PPA = 0.64) and 78.5 (NPA = 0.5 PPA = 0.79), respectively. Louis University Mental Status (SLUMS, reference standard) and Cognivue ® tests.
For the cut-off score determination study, 92 participants completed St.
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